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Researchers have not long ago determined and succeeded in synthesizing conolidine, a organic compound that displays promise as being a potent analgesic agent with a far more favorable protection profile. Even though the precise mechanism of action continues to be elusive, it is currently postulated that conolidine might have many biologic targets. … Read More

Though the opiate receptor depends on G protein coupling for sign transduction, this receptor was observed to utilize arrestin activation for internalization with the receptor. Normally, the receptor promoted no other signaling cascades (59) Modifications of conolidine have resulted in variable improvement in binding efficacy. This binding in the l… Read More

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